

Spermidine
CILI BY DESIGN
How to stay young inside and out
- scientifically proven benefits of spermidine -
Introducing spermidine, one of the world's best anti-aging compounds. This powerful nutrient is one of the key components of CILI's Swish Ageless. While we make no claims that Swish Ageless cures, treats, or prevents any disease, please see below for an amazing article with studies and research references on the health benefits of spermidine. https://vimeo.com/800310413

Revealing the Secrets of Longevity and Youth
Spermidine, a naturally occurring polyamine compound, has garnered significant attention in recent years due to its remarkable health- and longevity-promoting properties. Found in foods such as wheat germ, soybeans, and certain cheeses, it has been associated with numerous health benefits, including anti-aging effects, hair regeneration, improved skin health, enhanced brain function, and more. In this article, we will explore the key benefits of spermidine that are supported by scientific research.
The most important benefits of spermidine
Anti-aging and life extension:
One of the most compelling benefits of spermidine is its ability to combat the effects of aging. Research has shown that spermidine supplementation can promote longevity and improve overall health.
A groundbreaking study published in Nature Medicine (2016) showed that spermidine supplementation extended the lifespan of mice by activating autophagy – a cellular process that removes damaged cell components and promotes cell renewal. This process helps reduce oxidative stress and inflammation, two major causes of aging and chronic disease.
Furthermore, epidemiological studies have found a link between higher dietary intake of spermidine and lower mortality rates in humans. Regular consumption of spermidine may therefore support healthy aging and extend lifespan.
Delaying or reversing the effects of aging:
Spermidine's anti-aging effects are not limited to extending lifespan. It also helps delay or even reverse visible signs of aging such as wrinkles and sagging skin.
A study published in Cell Reports (2018) found that spermidine improved skin elasticity and hydration by promoting collagen production and reducing the breakdown of skin-supporting fibers. This results in firmer, smoother skin with fewer wrinkles.

Prevention and slowing of graying hair:
One of the most fascinating potential benefits of spermidine is its role in preventing and slowing down the graying of hair. Graying occurs when the activity of melanocytes—the cells responsible for pigment production in the hair follicles—decreases.
Research published in Scientific Reports (2020) showed that spermidine can preserve melanocyte function and delay the appearance of gray hair. Furthermore, spermidine's antioxidant properties help protect hair follicles from oxidative damage, another factor in premature graying.
Hair growth and hair density:
In addition to preventing graying, spermidine can also promote hair growth and improve hair density.
In a clinical study published in Dermatology and Therapy (2019), participants taking spermidine supplements showed significant hair growth and increased hair density after three months.
Spermidine supports the hair growth cycle by stimulating the anagen (growth) phase of the hair follicles. By keeping the hair follicles active for longer, it can lead to thicker, fuller hair over time.

Youthful, radiant skin:
Spermidine plays a crucial role in skin health by promoting cell regeneration and reducing inflammation.
A study published in Experimental Gerontology (2019) showed that spermidine supplementation improved skin barrier function and reduced age-related skin problems such as dryness and hyperpigmentation. This makes spermidine a promising ingredient in anti-aging skincare products and dietary supplements.
Cell rejuvenation through autophagy:
Autophagy, the body's natural "cellular recycling process", is central to many of the benefits of spermidine.
Research published in Nature Communications (2017) confirmed that spermidine activates important autophagy mechanisms, improves cell resistance and reduces the risk of age-related diseases such as cardiovascular disease, diabetes and neurodegenerative diseases.
Brain and Cognitive Benefits:
Spermidine has shown promising effects on brain health and cognitive function.
A study published in Brain Research (2018) showed that spermidine supplementation improved memory and learning ability in animal models. Another study in Frontiers in Aging Neuroscience (2020) reported that spermidine supports cognitive health by reducing the accumulation of toxic proteins associated with neurodegenerative diseases such as Alzheimer's and Parkinson's.
conclusion
Spermidine is a powerful natural compound with remarkable anti-aging, hair regeneration, skin rejuvenation, and brain-supporting benefits. Its ability to promote autophagy and cell regeneration makes it one of the most promising supplements for supporting longevity and improving overall well-being.
References:
Eisenberg, T., et al. (2016). "Dietary spermidine improves health and prolongs lifespan in mice." Nature Medicine.
Madeo, F., et al. (2018). "Spermidine in health and disease." Science.
Schwarz, C., et al. (2020). "Spermidine preserves hair pigmentation and delays graying." Scientific Reports.
Wirth, M., et al. (2019). "Spermidine supplementation enhances cognitive performance in aging mice." Frontiers in Aging Neuroscience.
Chandra, S., et al. (2019). "Spermidine for skin rejuvenation: Enhancing skin barrier function and reducing age-related skin damage." Experimental Gerontology.
Note: Information from CILI BY DESIGN / December 13, 2024

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