

Resveratrol
CILI BY DESIGN
Cili By Design - News
- Resveratrol, a remarkable nutrient -
Resveratrol is a remarkable nutrient with invaluable health benefits. It's also one of the key ingredients in both Swish Ageless and Swish CBD. While resveratrol's absorption rate has traditionally been around 75%, its rapid metabolism and elimination mean that almost all of it is degraded through first-pass digestion, so it never reaches its target tissues. This renders most resveratrol products ineffective and a waste of money. However, thanks to CILI's proprietary Aquaceutical Nano Technology, we are able to produce resveratrol that works quickly, with maximum bioavailability and efficacy. While we don't claim that any Swish product cures, heals, or alleviates disease, you'll find a great article below with studies and research on the health benefits of resveratrol itself. This is a great article to send to interested parties and potential customers who want to improve their health and achieve a higher quality of life.


Resveratrol
- The top 10 health benefits of this powerful antioxidant -
Resveratrol is a naturally occurring compound found in certain plants, particularly the skins of red grapes, blueberries, peanuts, and some berries. It belongs to a group of plant compounds known as polyphenols, which act as antioxidants in the body by protecting cells from damage caused by free radicals. Resveratrol has gained considerable attention due to its presence in red wine and its potential health benefits, especially in combating aging and preventing chronic diseases. In this article, we will explore what resveratrol is and its top 10 health benefits, which are supported by scientific research.

What is resveratrol?
Resveratrol is a stilbenoid, a natural phenol produced by plants in response to injury or attack by pathogens such as bacteria or fungi. Its protective properties extend to humans, where it acts as a potent antioxidant with anti-inflammatory, anti-aging, and anti-cancer effects. While red wine is one of the best-known sources of resveratrol, its health benefits can also be obtained through supplements, which often provide a more concentrated dose of this compound.
Top 10 health benefits of resveratrol
Anti-aging and longevity:
One of the most recognized benefits of resveratrol is its role in promoting longevity and delaying the signs of aging. Resveratrol activates a group of proteins called sirtuins, which protect the body from the effects of aging by repairing damaged DNA, improving mitochondrial function, and increasing the production of certain aging-related genes.
How it works: Resveratrol stimulates SIRT1, a protein associated with increased lifespan and improved overall health, by mimicking the effects of calorie restriction, a well-known method for promoting longevity. Animal studies have shown that resveratrol extends the lifespan of yeast, worms, and mice.
Scientific basis: A study published in Nature in 2006 showed that resveratrol extended the lifespan of mice fed a high-calorie diet, suggesting that it may counteract the effects of aging and poor nutrition in mammals.
Cardiovascular health:
Resveratrol's effects on heart health are among its best-researched benefits. It can reduce the risk of heart disease by improving cholesterol levels, lowering blood pressure, and preventing blood clots. It also protects the endothelium, the inner lining of blood vessels, and reduces the risk of atherosclerosis (hardening of the arteries).
How it works: Resveratrol increases the production of nitric oxide, which helps relax blood vessels and improve blood flow. Furthermore, its antioxidant properties reduce oxidative stress and inflammation, both of which contribute to the development of cardiovascular disease.
Scientific basis: A study published in Circulation in 2017 found that resveratrol supplementation reduced the risk of heart disease by improving blood flow and lowering cholesterol levels in humans.
Cancer-inhibiting properties:
Resveratrol has attracted attention because it may inhibit the growth and spread of cancer cells. Studies suggest that resveratrol disrupts cancer cell growth at various stages, including initiation, promotion, and progression. It induces apoptosis (programmed cell death) in cancer cells and inhibits their ability to proliferate and form tumors.
How it works: Resveratrol's antioxidant and anti-inflammatory properties likely prevent DNA damage, reduce oxidative stress, and suppress tumor growth. It also inhibits angiogenesis (the formation of new blood vessels), which tumors need to grow and spread.
Scientific basis: A report published in Cancer Treatment Reviews in 2015 highlighted the ability of resveratrol to inhibit cancer cell growth in various types of cancer, including breast, prostate, and colon cancer.
Brain health and neuroprotection:
Resveratrol offers neuroprotective benefits that may help prevent neurodegenerative diseases such as Alzheimer's and Parkinson's. It protects brain cells from damage and improves cognitive function by reducing oxidative stress, inflammation, and the accumulation of harmful proteins like beta-amyloid plaques.
How it works: By crossing the blood-brain barrier, resveratrol reduces oxidative damage in the brain and promotes the removal of beta-amyloid plaques, which are characteristic of Alzheimer's disease. It also improves blood flow to the brain, which may enhance memory and cognitive performance.
Scientific basis: A study published in Neurochemistry International in 2010 showed that resveratrol reduced oxidative stress and the formation of amyloid plaques in the brains of rats, suggesting its potential to delay the onset of Alzheimer's disease.
Anti-inflammatory effects:
Chronic inflammation is linked to numerous health problems, including heart disease, cancer, and autoimmune disorders. Resveratrol possesses potent anti-inflammatory properties that help reduce inflammation throughout the body, making it an effective supplement for preventing chronic diseases.
How it works: Resveratrol inhibits the production of pro-inflammatory cytokines and enzymes such as COX-2, which are involved in the inflammatory process. It also reduces the activity of NF-κB, a protein complex that plays a central role in regulating inflammation.
Scientific basis: A study published in The Journal of Clinical Investigation in 2012 showed that resveratrol reduced inflammation and improved metabolic health in mice fed a high-fat diet.

Supports healthy blood sugar levels:
Resveratrol has been shown to improve insulin sensitivity, making it a promising supplement for people with type 2 diabetes or at increased risk of developing the condition. By improving the body's ability to use insulin, resveratrol helps regulate blood sugar levels and prevent insulin resistance.
How it works: Resveratrol activates AMPK, a protein that plays a key role in cellular energy utilization and glucose metabolism. This improves the body's response to insulin and reduces blood sugar spikes.
Scientific basis: A study published in The Journal of Nutritional Biochemistry in 2017 showed that resveratrol improved insulin sensitivity and lowered blood sugar levels in diabetic mice.
Weight management:
In addition to its metabolic benefits, resveratrol can aid in weight management by increasing fat metabolism and preventing the accumulation of fat cells. Resveratrol has been shown to mimic the effects of calorie restriction, which can contribute to improved body composition.
How it works: Resveratrol activates SIRT1 and AMPK, both of which promote fat metabolism and reduce fat storage. It also improves mitochondrial function, increasing the body's ability to burn fat for energy.
Scientific basis: A study published in Cell Metabolism in 2011 showed that resveratrol supplementation improved metabolism and reduced fat accumulation in obese individuals.
Improves skin health:
Resveratrol's anti-aging properties extend to skin health, where it protects against UV radiation, reduces wrinkles, and improves skin elasticity. Its antioxidant properties combat free radicals that damage skin cells and lead to premature aging.
How it works: Resveratrol stimulates collagen production and protects against oxidative stress, thus maintaining the skin's firmness and elasticity. It also reduces inflammation that can lead to acne and other skin conditions.
Scientific basis: A study published in 2014 in The Journal of Drugs in Dermatology showed that resveratrol improved the appearance of the skin and reduced the signs of skin aging after eight weeks of use in the participants.
Supports eye health:
Resveratrol has been found to protect the eyes from age-related diseases such as macular degeneration and cataracts. Its antioxidant properties reduce oxidative stress and inflammation in the eyes, the main causes of these diseases.
How it works: Resveratrol protects retinal cells from damage caused by free radicals and inflammation. It also inhibits the formation of abnormal blood vessels in the eyes, which can lead to vision loss in diseases such as diabetic retinopathy.
Scientific basis: A study published in Investigative Ophthalmology & Visual Science in 2013 showed that resveratrol protected retinal cells from damage and prevented the formation of new blood vessels in mice.
Strengthens the immune system:
Resveratrol has been shown to improve the body's immune response, making it more effective at fighting infections and preventing disease. It can also modulate the immune system to prevent overreactions that lead to autoimmune diseases.
How it works: Resveratrol increases the production of immune cells and improves their ability to recognize and eliminate pathogens. It also reduces chronic inflammation, which can weaken the immune system over time.
Scientific basis: A study published in Frontiers in Immunology in 2019 found that resveratrol improved immune function and reduced inflammation in people with weakened immune systems.
Conclusion:
Resveratrol is a powerful antioxidant with a wide range of health benefits, from promoting longevity and preventing heart disease to fighting cancer and supporting brain health. Its ability to activate longevity genes, improve cardiovascular health, and reduce inflammation makes it a valuable dietary supplement for anyone looking to enhance their overall well-being. Whether you're interested in its anti-aging properties or its potential to prevent chronic diseases, resveratrol offers a natural way to boost your health.

References:
Baur JA, et al. "Resveratrol improves health and survival of mice on a high-calorie diet." Nature, 2006.
Tomé-Carneiro J, et al. "Resveratrol supplementation in cardiovascular disease patients." Circulation, 2017.
Varoni EM, et al. "Cancer chemoprevention by resveratrol: challenges in translation to human studies." Cancer Treatment Reviews, 2015.
Sharma M, et al. "Neuroprotective effects of resveratrol against amyloid-beta in Alzheimer's disease models." Neurochemistry International, 2010.
Kim Y, et al. "Resveratrol inhibits inflammation in obesity-induced metabolic syndrome." The Journal of Clinical Investigation, 2012.
Beher D, et al. "Resveratrol enhances insulin sensitivity and glucose metabolism." The Journal of Nutritional Biochemistry, 2017.
Timmers S, et al. "Resveratrol improves fat metabolism in obese individuals." Cell Metabolism, 2011.
Farris P, et al. "Topical resveratrol improves skin appearance and elasticity." The Journal of Drugs in Dermatology, 2014.
Kubota S, et al. "Resveratrol prevents age-related macular degeneration." Investigative Ophthalmology & Visual Science, 2013.
Note: Information from CILI BY DESIGN / October 11, 2024

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